FIGURE

Fig. 4

ID

ZDB-FIG-160812-3

Publication

Kim et al., 2014 - Developmental roles of D-bifunctional protein-A zebrafish model of peroxisome dysfunction

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Fig. 4

dbp knockdown affects development of blood, blood vessels and digestive organs. Embryos carrying different transgenes were used to determine tissue-specific effects upon dbp knockdown. (A-D) dbp knockdown affects red blood cell development and blood vessel patterning. Upon dbp knockdown, blood cells were severely reduced [shown by gata1:RFP transgenic line, (A) and (B)] and blood vessels were formed abnormally [shown by fli1:EGFP, (C) and (D)]. (E-H) dbp knockdown on doubly transgenic fish line (lfabp: DSRED in liver and elastase:GFP in pancreas) shows significantly reduced liver size (F) and absence of pancreas (H). Representative embryos at 3 dpf are shown in lateral view with anterior to the left, except (G) and (H) where presented in lateral view with anterior to the right.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gz15Tg + MO1-hsd17b4 ko05Tg + MO1-hsd17b4 y1Tg + MO1-hsd17b4
Knockdown Reagent:	MO1-hsd17b4
Observed In:	branching involved in blood vessel morphogenesis liver nucleate erythrocyte pancreas
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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