FIGURE

Fig. 1

ID

ZDB-FIG-160602-11

Publication

McCarthy et al., 2016 - Pdgfra and Pdgfrb genetically interact during craniofacial development

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Fig. 1

pdgfra and pdgfrb interact during craniofacial development. A-D: Five days postfertilization flatmounted zebrafish neurocrania. Anterior is to the left. A-C: Wild-type (A) and pdgfrb mutants (B) display normal craniofacial skeletons, while pdgfra mutants (C) display a shortened neurocrania and cleft palate (asterisk). D: pdgfra;pdgfrb double mutants lose the palatal skeleton (arrowheads) and a region of the parachordals adjacent to the posterior basicapsular commissure (arrows). E: Bar chart depicting neurocranial length measured from the anterior ethmoid plate to the posterior occipital arch of the neurocranium. Similarly shaded bars are not significantly different from one another (ANOVA, P ≤ 0.05). F: Bar chart depicting percent of phenotypes observed per genotype listed showing higher percentage of pdgfra^-/-;pdgfrb^-/- mutants displaying trabeculae loss, blue bar depicts cleft ethmoid plate (asterisk in C) and red bar depicts loss of trabeculae (arrowheads in D). ep, ethmoid plate; o, occipital arch; pbc, posterior basicapsular commissure; pc, parachordals; tr, trabeculae. Scale bar = 20 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pdgfra^b1059/b1059 pdgfrb^um148/um148 pdgfra^b1059/+ pdgfrb^um148/+ pdgfra^b1059/+; pdgfrb^um148/+ pdgfra^b1059/+; pdgfrb^um148/um148 pdgfra^b1059/b1059; pdgfrb^um148/+ pdgfra^b1059/b1059; pdgfrb^um148/um148
Observed In:	embryonic neurocranium morphogenesis ethmoid cartilage neurocranial trabecula neurocranium parachordal cartilage roof of mouth development
Stage:	Day 5

Phenotype Detail

Acknowledgments

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