FIGURE

Fig. 6

ID

ZDB-FIG-160425-8

Publication

Cofer et al., 2016 - Methylation Microarray Studies Highlight PDGFA Expression as a Factor in Biliary Atresia

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Fig. 6

Activation of the HH pathway upregulates PDGF. Larvae were incubated in 30µM purmorphamine, a HH receptor agonist, at 2dpf. (A) PED-6 gallbladder uptake shows decreased gallbladder staining in incubated larvae (p≤.00001) (B) PDGF-AA protein expression of purmorphamine-incubated larvae relative to the control (ctrl) at 5dpf. (B′) PDGF-AA protein quantification of two independent experiments with standard deviations. (C,D) Confocal projections of cytokeratin-18 immunostaining of livers from 5dpf control (ctrl) and purmorphamine (pur) incubated larvae. Numbers refer to individuals exhibiting comparable morphology as representative image.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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