FIGURE

Fig. 5

ID

ZDB-FIG-160414-14

Publication

Langdon et al., 2016 - Split top: A maternal cathepsin B that regulates dorsoventral patterning and morphogenesis

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Fig. 5

Convergent extension in split top embryos. Expression of (A) brachyury, (B) tbx16, (C,D) pax2.1, (D) krox20 and (C,D) myod indicates an expansion of the midline (probably combined with increased midline mesoderm tissue) and reduced extension in split top mutants. Additionally, whereas krox20 marks rhombomeres 3 and 5 in wild-type embryos, in split top mutants a single krox20 stripe is evident, indicating a loss of either rhombomeres 3 or 5, or a delay in rhombomere 5 expression. Black arrows mark the anterior-most wild-type expression domain and red arrows the anterior-most split top expression domain. The dorsal midline tissue is marked by T-bars in wild-type (black or white) and split top (red) mutants. The brackets indicate the distance from the anterior-most point of the embryo to the neural markers. In A,B, anterior is to top; in C,D, anterior is to left.

Expression Data

Genes:	egr2b myod1 pax2a tbx16 tbxta
Fish:	TL ctsba^p24bdth/+ (TL)
Anatomical Terms:	adaxial cell hindbrain neural keel neural plate notochord paraxial mesoderm presumptive rhombomere 3 presumptive rhombomere 5 segmental plate somite tail bud
Stage Range:	Bud to 5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ctsba^p24bdth/+ (TL)
Observed In:	adaxial cell convergent extension hindbrain neural keel neural plate notochord paraxial mesoderm segmental plate somite
Stage Range:	1-4 somites to 5-9 somites

Phenotype Detail

Acknowledgments

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