FIGURE

Fig. 4

ID

ZDB-FIG-160411-13

Publication

Marra et al., 2016 - Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development

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Fig. 4

Redundancy between etv5a and etv4 in MCC formation. (A) In embryos injected with either etv5a MO, etv4 MO, or a combination of etv5a MO and etv4 MO, there is reduced expression of odf3b (purple), where the greatest loss appears in the absence of both etv5a and etv4 transcripts. (B) A significant decrease in average MCC number results in the loss of etv5a, as well as the loss of etv4. Injection of etv5a and etv4 together caused a greater decrease in the average number of MCCs. Representative images are shown for the quantified groups (n>50 for each), and standard error is depicted by the error bars. p-values: *****p<0.001, ****p<0.002.

Expression Data

Gene:	cimap1b
Fish:	WT WT + MO1-etv5a WT + MO2-etv4 WT + MO1-etv5a + MO2-etv4
Knockdown Reagents:	MO1-etv5a MO2-etv4
Anatomical Term:	pronephros multi-ciliated epithelial cell
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-etv5a WT + MO2-etv4 WT + MO1-etv5a + MO2-etv4
Knockdown Reagents:	MO1-etv5a MO2-etv4
Observed In:	pronephric nephron tubule epithelial cell differentiation pronephros pronephros multi-ciliated epithelial cell pronephros multi-ciliated epithelial cell differentiation
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 411(2), Marra, A.N., Wingert, R.A., Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development, 231-45, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.