FIGURE

Fig. 4 S2

ID

ZDB-FIG-160324-4

Publication

Zhang et al., 2016 - An oxygen-insensitive Hif-3α isoform inhibits Wnt signaling by destabilizing the nuclear β-catenin complex

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Fig. 4 S2

Effects of Hif-3α2, Hif-3α1′ (a stabilized Hif-3α1), and Hif-1α′ (a stabilized Hif-1α) on Wnt3a- (A) and β-cateninΔN-induced (B) Topflash activity.Embryos injected with 90 pg Topflash plasmid DNA together with the indicated capped mRNA (600 or 800 pg) were raised to 9 hpf in normoxic water and luciferase activity was measured. Values are means +S.E. (n = 3). *, **, and ***p < 0.05, 0.01 and 0.001. ns, not significant. (C) Hif-3α2 overexpression antagonizes Wnt3a and β-cateninΔN actions. Zebrafish embryos were injected with the indicated capped mRNA. They were raised and photographed at 12 hpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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