FIGURE

Fig. 4

ID

ZDB-FIG-160317-34

Publication

Liu et al., 2016 - Cannabinoid receptor signaling regulates liver development and metabolism

Other Figures

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Fig. 4

Metabolic dysregulation and aberrant histological features persist in adult Cnr mutants. (A) H&E-stained adult liver sections show evidence of cholestasis (inset) and inflammatory infiltrates in cnr1^-/- mutants. cnr2^-/- mutants exhibit abnormal cellular morphology with increased open cytoplasm, suggesting extensive steatosis. (B) Adult liver sections stained for biliary marker 2F11 and with DAPI reveal decreased biliary tree formation in cnr1^-/- mutants and cholestatic deposits (arrows) in cnr2^-/- mutants. (C) Serum triglyceride content in male (C) and female (D) mutants. Adult cnr2^-/- zebrafish have doubled triglyceride levels compared with WT and cnr1^-/-. Mean±s.e.m.; n>5. One-way ANOVA. **P<0.01 for WT versus cnr2^-/-. Scale bars: 0.1mm.

Expression Data

Antibody:	Ab-2F11
Fish:	TU cnr1^zf679/zf679 (TU) cnr2^zf680/zf680 (TU)
Anatomical Term:	common bile duct
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cnr1^zf679/zf679 (TU) cnr2^zf680/zf680 (TU)
Observed In:	bile common bile duct common bile duct development hepatocyte liver liver lipid liver triglyceride
Stage:	Adult

Phenotype Detail

Acknowledgments

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