FIGURE

Fig. 4

ID

ZDB-FIG-160211-11

Publication

Shen et al., 2015 - RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

RUNX1-Evi-1 reprogrammed lineage-specific hematopoietic transcription factors. Scl (a), lmo2 (b) and gata2 (c) were detected by qRT-PCR in WT, and Tg(RE:HSE:EGFP) F2 generation embryos at 12 hpf, 18 hpf and 24 hpf. Gata1 (d), pu.1 (e), mpo (f), runx1(g), and c-myb (h) expressed in WT, Tg F2 zebrafish at 1 dpf, 3 dpf, 7 dpf and 60 dpf. Compared with WT, scl, gata2, pu.1, and c-myb were up-regulated, while gata1, mpo, and runx1 were down-regulated in Tg fish. In situ hybridization of scl (i-j), lmo2 (k-l), gata2 (m-n), and gata1 (o-p) at 24hpf and mpo (q-r) at 30hpf in WT and Tg F2 embryos demonstrated the same tendency. *P < 0.05; **P < 0.01

Expression Data

Genes:	gata1a gata2a lmo2 mpx myb runx1 spi1b tal1
Fish:	AB zf685Tg
Condition:	heat shock
Anatomical Terms:	anatomical structure intermediate cell mass of mesoderm neutrophil posterior lateral mesoderm whole organism
Stage Range:	14-19 somites to Days 45-89

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf685Tg
Condition:	heat shock
Observed In:	anatomical structure intermediate cell mass of mesoderm neutrophil posterior lateral mesoderm whole organism
Stage Range:	14-19 somites to Days 45-89

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Cancer