FIGURE

Fig. 4

ID

ZDB-FIG-160208-19

Publication

Sisson et al., 2015 - A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis

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Fig. 4

The gpc4 mutant craniofacial phenotype is not enhanced by the loss of wnt5b. (A–B) The length of the symplectic element (see inset) from 5 dpf embryos. (A) Measurements of the symplectics from progeny of a dihybrid cross of gpc4^m818 and wnt5b^ta98. The presence of wnt5b^ta98 does not enhance the gpc4^m818 phenotype, but the double heterozygous mutant is significantly different than wild type. Tests of 14 a priori hypotheses were conducted using a Bonferroni adjusted alpha level of 0.00357 (0.05/11). *p = 0.0015, Mann–Whitney U (df) = 20. **p = 0.0021, Mann–Whiney U (df) = 88. (B) The symplectic cartilage is significantly smaller in gpc^4fr6 mutants than the symplectic elements in gpc4^m818 mutants. *p = 0.0157, Mann–Whitney U (df) = 22. Abbreviations: sy = symplectic, hm = hyomandibular.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gpc4^fr6/fr6 gpc4^m818/m818 wnt5b^ta98/ta98 gpc4^m818/+ wnt5b^ta98/+ gpc4^m818/+; wnt5b^ta98/+ gpc4^m818/+; wnt5b^ta98/ta98 gpc4^m818/m818; wnt5b^ta98/+ gpc4^m818/m818; wnt5b^ta98/ta98
Observed In:	symplectic
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 138 Pt 3, Sisson, B.E., Dale, R.M., Mui, S.R., Topczewska, J.M., Topczewski, J., A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis, 279-90, Copyright (2015) with permission from Elsevier. Full text @ Mech. Dev.