FIGURE
Fig. 8
- ID
- ZDB-FIG-160205-46
- Publication
- Hesse et al., 2015 - The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration
- Other Figures
- All Figure Page
- Back to All Figure Page
Fig. 8
Model of ARF function in the context of Rb pathway activity during zebrafish development and fin regeneration.ARF is not active during development during which a moderate level of mitogenic signaling causes modest phosphorylation of Rb1 (top); however, during regeneration, high mitogenic signaling induces Rb1 hyperphosphorylation and abundant free E2f1, which activates ARF and leads to inhibition of regeneration (bottom). The dashed lines represent the amputation plane. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Elife