FIGURE

Fig. S3

ID

ZDB-FIG-151207-7

Publication

Karra et al., 2015 - Myocardial NF-κB activation is essential for zebrafish heart regeneration

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Fig. S3

NF-_KB signaling contributes to cardiomyocyte dedifferentiation. (A and B) Representative images of 7 dpa ventricles from cmlc2:CreER; βact2:RS-I_KBSR treated with vehicle (n = 6) or 4-HT (n = 7) stained for Tnnt (gray). Arrowheads show diminished Tnnt staining in cardiomyocytes adjacent to the wound in control animals, suggestive of sarcomere disassembly. (C) Quantification of intensity of Tnnt intensity per muscle area suggests decreased sarcomere disassembly in ventricles with defective NF-_KB signaling (n = 13). (D and E) Section images of 7 dpa ventricles from cmlc2:CreER; βact2:RS-I_KBSR; gata5:eGFP fish treated with vehicle (n = 5) or 4-HT (n = 5). eGFP fluorescence is shown in grayscale. *P < 0.05, Student’s t test, two-tailed. (Scale bars: 100 µm.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA