Fig. 4, S4
- ID
- ZDB-FIG-151125-29
- Publication
- Singh et al., 2015 - Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish
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The heat shock promoter is not suppressed in hcrtr or dbh mutants. Representative images of brains from larvae that do not (A) or do (B) contain the hsp:Hcrt transgene, fixed 30 min after HS, and processed for ISH using a hcrt-specific probe. hcrt overexpression levels are similar for hcrtr+/- (B), hcrtr-/- (B′), dbh+/- (B′′) and dbh-/- (B′′′) animals. Larvae were generated by crossing homozygous to heterozygous mutant animals, and brains were genotyped after imaging. Dark spots in (A-A′′′) are pigment cells. Endogenous hcrt expression is not observed in (A–A′′′) because ISH development was stopped before endogenous hcrt is detectable. |