FIGURE

Fig. 1

ID

ZDB-FIG-151125-20

Publication

Okuda et al., 2015 - A zebrafish model of inflammatory lymphangiogenesis

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Fig. 1

Colitogenic challenge is associated with increased intestinal lymphangiogenesis. (A-C) Lateral images of lyve1:DsRed2;kdrl:EGFP larvae at 7dpf (A), treated with TNBS (B) or DSS (C). Asterisks indicate intestinal lymphatic sprouts (ILSs). A′-C′ shows the left intestinal vasculature and A′′′-C′′′ shows the trunk vasculature in the DsRed channel only. A′′-C′′ are schematic diagrams of arteries (red), veins (blue), lymphatic vessels (green) and ILS (magenta) of A-C. (D-G) Quantification of ILS number (D,E) and total ILS length (F,G) in TNBS (D,F) and DSS (E,G) treated larvae compared with untreated, 5-aminosalicylic acid (5-ASA), and TNBS/DSS+5-ASA (ne20). Error bars, ±s.d. *P<0.05, **P<0.01, ***P<0.001 by one-way ANOVA with Dunnett′s multiple comparison test. DA, dorsal aorta; L-IL, left intestinal lymphatics; PCV, posterior cardinal vein; TD, thoracic duct. Scale bar: 100µm.

Expression Data

Genes:	DsRed EGFP
Fish:	nz101Tg; s843Tg
Conditions:	chemical treatment: dextran sulfate chemical treatment: 2,4,6-trinitrobenzenesulfonic acid
Anatomical Terms:	blood vasculature intestinal lymphatic network intestinal lymphatic network lymphangiogenic sprout intestine blood vasculature lymphatic system posterior cardinal vein thoracic duct trunk lymphatic system trunk vasculature blood vasculature vein
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nz101Tg; s843Tg
Conditions:	chemical treatment: dextran sulfate chemical treatment: dextran sulfate chemical treatment: 2,4,6-trinitrobenzenesulfonic acid chemical treatment: 2,4,6-trinitrobenzenesulfonic acid
Observed In:	intestinal lymphatic network lymphangiogenesis intestinal lymphatic network lymphangiogenic sprout trunk lymphangiogenesis
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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