FIGURE

Fig. 3

ID

ZDB-FIG-150520-13

Publication

Ju et al., 2015 - Oncogenic KRAS promotes malignant brain tumors in zebrafish

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Fig. 3

Histological and immunohistological analyses of tumors fromkrt5andgfaptransgenic fish. (A) H&E staining of a sagittal section from a 6-month-old krt5-derived tumor showing tumor cells originating from and infiltrating the VZ of the optic tectum (OT), as highlighted by the dotted line. (B) Enlarged view of the white frame in (A) demonstrating infiltrating malignant cells with moderate pleomorphism, typical of high-grade astrocytoma. (C) A 6-month-old gfap-transgenic fish brain showing tumor development in both the VZ (broken line) and the brain parenchyma (arrow). gfap:KRAS^G12V-derived brain tumors exhibited phenotypes consistent with malignant glioma including frequent mitotic figures (D) and focal necrosis (E, F). N, necrosis. Scale bars, 100 µm for A; 20 µm for B, D, E and F; 40 µm for C.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Cancer