Fig. 8
- ID
- ZDB-FIG-150211-25
- Publication
- Paulus et al., 2014 - Loss of Optineurin In Vivo Results in Elevated Cell Death and Alters Axonal Trafficking Dynamics
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MZoptn embryos have defects in the dynamics of vesicle trafficking. A–J, M–P. Frames from time-lapse imaging of Texas Red-dextran trafficked through longitudinal spinal axons in WT (A–H) or MZoptn (M–P) embryos. Moving puncta are indicated by arrows and time codes are indicated. WT punctum shown in A–K traveled a little slower than average. MZoptn punctum shown in L–P traveled faster than average. K, L. Quantification of the speed of indicated puncta of WT panels (K) or MZoptn panels (L). Each time-point corresponds to the average speed of the puncta over the preceding 15 seconds. Q–T. Quantification of all puncta from WT and MZoptn embryos showing overall speed of puncta (Q), speed of puncta when they are not pausing (R), % of time puncta spend pausing (S) and time that each puncta spends on individual pauses (T). * indicates p≤0.05. |
| Fish: | |
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| Observed In: | |
| Stage: | Prim-5 |