FIGURE

Fig. 7

ID

ZDB-FIG-141112-16

Publication

Schindler et al., 2014 - Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration

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Fig. 7

hand2 overexpression limits expression of blood and vessel genes within the ALPM. (A-L) In situ hybridization depicts expression of (A,B) scl, (C,D) etsrp, (E,F) pu.1, (G,H) mef2cb, (I,J) nkx2.5 and (K,L) gata4 in (A,C,E,G,I,K) nontransgenic embryos and (B,D,F,H,J,L) Tg(hsp70:hand2) embryos following heat shock at 10hpf. Dorsal views, anterior upwards, at (A-J) 12 somites and (K,L) 10 somites. Overexpression of hand2 results in (A-F) decreased distribution of scl, etsrp and pu.1 expression, as well as (G,H) increased expression of mef2cb. By contrast, expression of (I,J) nkx2.5 and (K,L) gata4 appear relatively normal in hand2-overexpressing embryos at these stages.

Expression Data

Genes:	etsrp gata4 mef2cb nkx2.5 spi1b tal1
Fish:	WT sd28Tg
Condition:	heat shock
Anatomical Terms:	anterior lateral plate mesoderm cardiovascular system hematopoietic system myocardial precursor
Stage:	10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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