FIGURE

Fig. 3

ID

ZDB-FIG-140902-112

Publication

Li et al., 2014 - Zebrafish Adar2 Edits the Q/R Site of AMPA Receptor Subunit gria2alpha Transcript to Ensure Normal Development of Nervous System and Cranial Neural Crest Cells

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Fig. 3

Head morphology of hypo-Q/R-editing morphants.

(A) Bright-field images of morphants established in the wild type background between 24 to 72 hpf. The genotypes of the morphants are indicated on the top, where adar2MOc, adar2MOsp, adar2MOt, adar2MOt-p53^AUG and gria2αQRMO respectively indicate embryos receiving the mismatch morpholino (MOc), splicing blocker (MOsp), translation blocker (MOt), MOt plus p53-MO^AUG [22], and RNA editing blocker (QRMO) morpholinos. Developmental time is shown on the left. The brain ventricles are enlarged and the size of heads is reduced in the hypo-Q/R-editing morphants. (B) Bright-field images of p53 mutant (tp53^zdf1) receiving morpholinos described in (A) between 24 to 72 hpf. The morphological changes of adar2MO and gria2αQRMO cannot be suppressed by losing p53 activity.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-adarb1a WT + MO1-adarb1a + MO4-tp53 WT + MO1-gria2a WT + MO2-adarb1a tp53^zdf1/zdf1 + MO1-adarb1a tp53^zdf1/zdf1 + MO1-gria2a tp53^zdf1/zdf1 + MO2-adarb1a
Knockdown Reagents:	MO1-adarb1a MO1-gria2a MO2-adarb1a MO4-tp53
Observed In:	fourth ventricle head third ventricle
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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