FIGURE

Fig. 4

ID

ZDB-FIG-140618-21

Publication

Quillien et al., 2014 - Distinct Notch signaling outputs pattern the developing arterial system

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Fig. 4

Multiple Notch receptors contribute to artery differentiation. (A,B) Confocal micrographs of flat-mounted sibling embryos at 10 ss following fluorescence in situ hybridization with riboprobes against egfp (green) and etv2 (red). Dorsal view, anterior is up. (A) Wild type Tg(tp1:egfp)^um14; arrows indicate etv2/egfp double-positive cells. (B) Tg(tp1:egfp)^um14;notch3^fh332 mutant sibling. (C-F) DIC images of Tg(tp1:egfp)^um14 wild-type (left panels) and notch3^fh332 mutant (right panels) embryos at 24 hpf subjected to in situ hybridization with riboprobes against egfp (C,E) or efnb2a (D,F); (C,D) Embryos injected with 2.5 ng control morpholino (MO). (E,F) Embryos injected with 2.5 ng notch1b MO. Scale bars: 40 μm (A,B); 50 μm (C-F).

Expression Data

Genes:	efnb2a EGFP etsrp
Fish:	um14Tg um14Tg + MO6-notch1b notch3^fh332/fh332; um14Tg notch3^fh332/fh332; um14Tg + MO6-notch1b
Knockdown Reagent:	MO6-notch1b
Anatomical Terms:	dorsal aorta endothelial cell intersegmental vessel
Stage Range:	10-13 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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