FIGURE

Fig. 6

ID

ZDB-FIG-140224-23

Publication

Mawdsley et al., 2004 - The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish

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Fig. 6

Neural progenitor populations are specified and positioned correctly in Neogenin morphants. (a) shh was expressed in the diencephalon (d) and floor plate (fp) within the developing brain and neural tube in control embryos (26 hpf). (b) The overall pattern of shh expression remained unaltered in the embryos injected with 3.7 ng ATG-MO, except for the dorsally directed peak of expression in the caudal diencephalon, which was reduced. (c) Expression of pax2.1 delineated the rostral domain of the midbrain-hindbrain boundary (mhb) in control embryos (26 hpf). (d) The pattern of pax2.1 expression was identical in the morphants indicating that mhb patterning was unaffected. (e) The expression of krox-20 in control embryos delineated rhombomeres 3 and 5 in the developing hindbrain (20 hpf). (f) The expression of krox-20 in the morphants was indistinguishable from control embryos. (a-f) Lateral views with rostral to the left and dorsal to the top.

Expression Data

Genes:	egr2b pax2a shha
Fish:	WT WT + MO2-neo1a
Knockdown Reagent:	MO2-neo1a
Anatomical Terms:	diencephalon floor plate midbrain hindbrain boundary rhombomere 3 rhombomere 5
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 269(1), Mawdsley, D.J., Cooper, H.M., Hogan, B.M., Cody, S.H., Lieschke, G.J., and Heath, J.K., The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish, 302-315, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.