FIGURE

Fig. 4

ID

ZDB-FIG-140102-2

Publication

Forbes-Osborne et al., 2013 - Insulinoma-associated 1a (Insm1a) is required for photoreceptor differentiation in the zebrafish retina

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Fig. 4

Knockdown of insm1a causes modest changes in cell number for some non-photoreceptor cell types. At 3 dpf the numbers of ganglion cells and bipolar cells were slightly reduced in insm1a morphant retinas, whereas the numbers of amacrine cells and Müller glia were not significantly affected. (*p<0.005; ^#p<0.003; mean±stdev for all; n=6 embryos each for ganglion and amacrine cells, 5 each for bipolar cells and 18 eyes from 10 embryos each for Müller glia).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-insm1a mi2001Tg + MO3-insm1a q16aTg; q16bTg + MO3-insm1a
Knockdown Reagent:	MO3-insm1a
Observed In:	amacrine cell Muller cell retinal bipolar neuron retinal ganglion cell
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 380(2), Forbes-Osborne, M.A., Wilson, S.G., and Morris, A.C., Insulinoma-associated 1a (Insm1a) is required for photoreceptor differentiation in the zebrafish retina, 157-171, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.