FIGURE

Fig. 5

ID

ZDB-FIG-131024-3

Publication

Abramsson et al., 2013 - The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation

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Fig. 5

Defective primary motor neurons. PMNs in the spinal cord of control embryos (A), trslMO (B) and trslMO +mRNA (C) injected Tg(mnx1:GFP) embryos (B) have dorsally projecting MiPs (arrow) and ventrally projecting CaP (arrowhead). Staining of control (D), trslMO (E) and trslMO +mRNA (F) injected embryos using znp1. CaP neurons stalling was observed in trslMO injected embryos (^N). Measurement of the length of CaP (G) and MiP (H). Bar is 20 μm. Two-way ANOVA test: ^NNNP<0.0005, ^NP<0.05, n.s.=not significant.

Expression Data

Gene:	GFP
Antibody:	znp-1
Fish:	ml2Tg (AB) ml2Tg + MO2-appb (AB)
Knockdown Reagent:	MO2-appb
Anatomical Terms:	CaP motoneuron interneuron primary motor neuron
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ml2Tg + MO2-appb (AB)
Knockdown Reagent:	MO2-appb
Observed In:	CaP motoneuron axon CaP motoneuron axon extension
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 381(2), Abramsson, A., Kettunen, P., Banote, R.K., Lott, E., Li, M., Arner, A., and Zetterberg, H., The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation, 377-88, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.