FIGURE

Fig. 3

ID

ZDB-FIG-130906-44

Publication

Czopka et al., 2013 - Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo

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Fig. 3

Mature Myelinating Oligodendrocytes Never Generate New Myelin Sheaths but Do Remove a Small Number over Time (A) Single mbp:EGFP-CAAX-expressing oligodendrocyte imaged from 4 through 20 dpf. Scale bar, 10 μm. (B) Quantification of myelin sheath number of individual myelinating oligodendrocytes over time. (C) Percentage of myelin sheath retractions over the time periods analyzed in (B). (D) Confocal images of a single myelinating process at 4 dpf (left) that is retracted slowly over the course of the following 3 days. Scale bar, 5 μm. See also Figure S3 and Movies S4 and S5.

Expression Data

Gene:	EGFP
Fish:	ue2Tg
Anatomical Term:	oligodendrocyte myelin sheath
Stage Range:	Day 4 to Days 14-20

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 25(6), Czopka, T., Ffrench-Constant, C., and Lyons, D.A., Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo, 599-609, Copyright (2013) with permission from Elsevier. Full text @ Dev. Cell