FIGURE

Fig. 1

ID

ZDB-FIG-130802-1

Publication

Shin et al., 2012 - Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Liver formation and the expression patterns of two hepatoblast markers, hhex and prox1, in wnt2bb mutants. (A-D) The Tg(fabp10:dsRed,ela3l:EGFP);Tg(ins:dsRed) line was used to reveal the liver (red), acinar pancreas (green), and pancreatic beta cells (red). Arrows point to the liver, arrowheads to the endocrine pancreas. The liver formed in most wnt2bb mutants (B and C), but its size was variable and smaller than wild-type. Dorsal views, anterior up. (E-T) hhex expression in the liver-forming region was weakly reduced in wnt2bb mutants compared to wild-type at 30 and 36 hpf (F and H, arrows), whereas prox1 expression was greatly reduced (N and P, arrows). hhex expression in the dorsal pancreas (E-H, arrowheads) and prox1 expression in the interrenal primordium (M-P, arrowheads) appeared unaffected in wnt2bb mutants compared to wild-type. To better visualize hepatic prox1 expression, side-view images are shown in an inset (M-P). Both hhex and prox1 are expressed in the developing liver, but only hhex is expressed in the extrahepatic duct (I-L, arrows). This extrahepatic duct expression appears unaffected in wnt2bb mutants (J and L, arrows). Dorsal views, anterior to the left. Scale bars, 100 µm.

Expression Data

Genes:	DsRed EGFP hhex prox1a
Fish:	WT wnt2bb^s403/s403 gz15Tg; m1018Tg wnt2bb^s403/s403; gz15Tg; m1018Tg
Anatomical Terms:	endocrine pancreas exocrine pancreas hepatic duct hepatoblast interrenal primordium liver pancreatic B cell posterior pancreatic bud
Stage Range:	Prim-15 to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	wnt2bb^s403/s403 wnt2bb^s403/s403; gz15Tg; m1018Tg
Observed In:	liver liver development
Stage Range:	Prim-15 to Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Mechanisms of Development, 128(11-12), Shin, D., Weidinger, G., Moon, R.T., and Stainier, D.Y., Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver, 525-535, Copyright (2012) with permission from Elsevier. Full text @ Mech. Dev.