FIGURE

Fig. 4

ID

ZDB-FIG-130719-30

Publication

Provost et al., 2013 - Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development

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Fig. 4

Morpholino-mediated knockdown of p53 does fail to rescue defective expansion of ptf1a-expressing pancreas progenitor cells in rpl mutant embryos. (A) Injection of embryos produced by rpl23a^{hi2582/ +} ;ptf1a:eGFP^jh1;ins:mCherry^jh2 incross with 1 ng p53ATG MO does not rescue hypoplastic pancreatic phenotype. (B) Incidence of abnormal pancreas development among embryos produced by rpl23a^{hi2582/ +} ;ptf1a:eGFP^jh1;ins:mCherry^jh2 incross injected with either p53ATG MO or mock control (phenotypic, red; wild type, blue). (C) Injection of embryos produced by rpl6^{hi3655b/ +} ;ptf1a:eGFP^jh1;ins:mCherry^jh2 incross with 1 ng p53ATG MO does not rescue hypoplastic pancreatic phenotype. (D) Incidence of abnormal pancreas development among embryos produced by rpl6^{hi3655b/ +} ;ptf1a:eGFP^jh1;ins:mCherry^jh2 incross injected with either p53ATG MO or mock control (phenotypic, red; wild type, blue). Color images available online at www.liebertpub.com/zeb

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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