FIGURE

Fig. 8

ID

ZDB-FIG-130524-24

Publication

Roach et al., 2013 - Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility

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Fig. 8

Smooth muscle and enteric neurons in ascl1a-/- at 4–5 dpf. Smooth muscle within the digestive system appears normal from proximal ((B) compared to (A)) to distal ((D) compared to (C)) in ascl1a−/− 5 dpf embryos as determined by desmin immunohistochemistry. Neuronal cell bodies highlighted by Elav 1 are numerous in both the proximal (E) and distal (G) WT intestine at 5 dpf but have been severely reduced in the proximal (F) and distal (H) ascl1a-/- intestine. Neurite density is also severely reduced in both the proximal (J) and distal (L) ascl1a-/- intestine when compared to WT proximal (I) and distal (K) as shown with acetylated tubulin. Scale bars represent 50 μm.

Expression Data

Antibodies:	Ab1-desm Ab1-elavl Ab1-tuba
Fish:	AB ascl1a^{t25215/t25215}
Anatomical Terms:	enteric circular muscle enteric longitudinal muscle enteric neuron neuron projection enteric neuron neuronal cell body
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ascl1a^{t25215/t25215}
Observed In:	enteric circular muscle enteric longitudinal muscle enteric nervous system enteric nervous system development enteric neuron
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 376(2), Roach, G., Heath Wallace, R., Cameron, A., Emrah Ozel, R., Hongay, C.F., Baral, R., Andreescu, S., and Wallace, K.N., Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility, 171-186, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.