FIGURE

Fig. 2

ID

ZDB-FIG-130514-1

Publication

Mei et al., 2013 - Mechanisms of prickle 1a function in zebrafish epilepsy and retinal neurogenesis

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Fig. 2

pk1a knockdown sensitizes zebrafish to PTZ treatment. (A-C) Morphology of wild-type and pk1a-MO-injected embryos at 2 dpf: wild-type uninjected embryo (A); pk1a-MO-injected embryos ranging from ‘normal-like’ (B) to curved body axis (C). (D) Graph of total half-hour activity before and after PTZ treatment for larvae injected with control-MO and pk1a-MO. Wilcoxon Rank Sum test found no significant increase (ns) in activity of control-MO and pk1a-MO injected larvae prior to PTZ treatment. There was a significant increase in activity in control after PTZ compared with control before PTZ (P<0.05) and for pk1a morphants after PTZ compared with before PTZ (P<0.05). *P<0.05 is the significant difference between control and pk1a morphant after PTZ treatment. For control-MO, n=48 and for pk1a-MO, n=48. Data presented as mean ± s.e.m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT WT + MO2-prickle1a
Condition:	chemical treatment: pentetrazol
Knockdown Reagent:	MO2-prickle1a
Observed In:	locomotory behavior whole organism anatomical axis
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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