FIGURE

Fig. 6

ID

ZDB-FIG-130502-44

Publication

Saxena et al., 2013 - Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish

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Fig. 6

Photo-morpholino knockdown of Sox10 demonstrates its necessity during the ingression/differentiation process.

(A) and (A′) Control (antisense morpholino + sense photo-morpholino injected but not photocleaved) live embryos have robust numbers of ciliated (red) and neural crest–derived microvillous (green) neurons at 38 hpf. In contrast, identically injected embryos subjected to photocleavage at 24 hpf go on to develop ciliated neurons but significantly lack microvillous neurons at 38 hpf (B and B′) in comparison to control embryos. Sox10:eGFP: green; OMP:RFP: red. Orientation arrows: D: dorsal; V: ventral; L: lateral. Scale bars: 30 μm. See also Figure 6—figure supplement 1.

Expression Data

Genes:	EGFP mRFP
Fish:	ba2Tg; rw035Tg ba2Tg; rw035Tg + MO2-sox10
Knockdown Reagent:	MO2-sox10
Anatomical Terms:	olfactory epithelium ciliated olfactory receptor neuron olfactory epithelium microvillous olfactory receptor neuron
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ba2Tg; rw035Tg + MO2-sox10
Knockdown Reagent:	MO2-sox10
Observed In:	olfactory epithelium olfactory epithelium ciliated olfactory receptor neuron olfactory epithelium microvillous olfactory receptor neuron
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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