FIGURE

Fig. 5

ID

ZDB-FIG-130228-22

Publication

Mo et al., 2012 - Apical Targeting and Endocytosis of the Sialomucin Endolyn are Essential for Establishment of Zebrafish Pronephric Kidney Function

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Fig. 5

Endolyn morphants develop pericardial edema, hydrocephaly, and body curvature. (A) Zebrafish larvae were imaged 48 hpf after endolyn MO injection and classified as wild type (no visible pericardial edema or body curvature), moderately affected (Class I: frank pericardial edema, visible body curvature, hydrocephaly) and severely affected or dead (Class II: severe pericardial edema, body curvature, severe hydrocephaly). Representative images from each class are shown. (B) The distribution of observed phenotypes at 48 hpf in embryos injected with control (Ctrl) MO or the indicated doses of endolyn (End) MOs is graphed. Endolyn knockdown elicits concentration-dependent effects on larval edema and survival. Three independent injections were quantified with 50 or more injected embryos per condition in each experiment.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-cd164
Knockdown Reagent:	MO1-cd164
Observed In:	brain pericardium whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.