FIGURE

Fig. S3

ID

ZDB-FIG-130222-10

Publication

Li et al., 2011 - Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation

Other Figures

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Fig. S3

Set8a acts synergistically with Wnt signaling in regulating zebrafish embryo development. (A) Set8a boosted the LEF1-luc in NIH 3T3. (B) In situ hybridization for expression of zebrafish set8a. set8a is broadly expressed at the 16-cell stage, sphere stage, and 60% epiboly. By 24 h postfertilization (hpf), set8a is more highly expressed in the brain region and blood island. Embryos hybridized with set8a sense probe were the negative control. (C) Injection of set8a mRNA rescued the set8a morphant phenotype. The morphants were classified into four categories: 0, S1, S2, and S3. (D) The set8a MO acted synergistically with the wnt8 MOs. The morphants were classified into four categories: 0, W1, W2, and W3.

Expression Data

Gene:	kmt5aa
Fish:	TU
Anatomical Terms:	blastoderm blastodisc brain intermediate cell mass of mesoderm
Stage Range:	16-cell to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA