FIGURE

Fig. 4

ID

ZDB-FIG-130118-36

Publication

Kaiser et al., 2012 - Amyloid Beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Apoptosis is synergistically increased when Appa and Prp1 levels are reduced. A–D.

Zebrafish injected with a control morpholino (MO), low dose (sub-effective) prp1 MO, low dose (sub-effective) appa MO, or a combination of sub-effective appa and prp1 MOs (A–D, respectively) showed increased abundance of activated-caspase 3-positive cells (A′–D′, respectively). Higher doses of MOs used in this same assay showed individual MOs can also produce this effect (Fig. S7). E. Activated caspase 3-positive cells were slightly increased when low doses of prp1 or appa MOs were injected alone and synergistically increased when they were combined in one injection solution. N = 5. ** = P<0.01, * = P<0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-prnpb + MO2-appa
Knockdown Reagents:	MO1-prnpb MO2-appa
Observed In:	obsolete positive regulation of cysteine-type endopeptidase activity
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One