FIGURE

Fig. 4

ID

ZDB-FIG-121220-13

Publication

Walogorsky et al., 2012 - Zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery

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Fig. 4

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Fig. 4

The effects of accelerated synaptic current decay on membrane repolarization. (A) Muscle cell voltage responses to the single firing of a motor neuron. Between 12 and 20 individual muscle responses were averaged to generate the average waveforms corresponding to 48-hpf wild-type (WT; gray), 48-hpf twi^+/− (black), and 120-hpf twi^+/− (red) fish. The scale bar represents 10 mV and 10 ms. (B) Comparison of the repolarization time course among 48-hpf wild-type (gray), 48-hpf twi^+/− (black), and 120-hpf (red) twi^+/− animals. (C) Sample traces for the first three sequential muscle responses to motor neuron firing at 20 Hz. Repolarization was incomplete for both 48-hpf (black traces) and 120-hpf (red traces) twi^+/− fish. However, the take-off level for responses 2 and 3 was much more positive at 48 hpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chrna1^{dtbn12/dtbn12}
Observed In:	membrane repolarization
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA