FIGURE

Fig. 1

ID

ZDB-FIG-121217-23

Publication

Zhao et al., 2012 - Dopaminergic neuronal loss and dopamine-dependent locomotor defects in fbxo7-deficient zebrafish

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Fig. 1

Characterization of the zFbxo7 protein in zebrafish.

(A) Schematic representation of the zFbxo7 functional domains. The values underneath each domain indicate the amino acids identity between zFbxo7 and hFBXO7 (isoform1). Ubl: ubiquitin-like domain; FP: FBXO7/ PI31 domain; F-box: F-box motif; PRR: proline rich domain. (B) Western blot analysis of the zFbxo7 protein expression at different developmental stages. (C) Western blot analysis of zFbxo7 protein expression in different tissues of eight-month-old adult zebrafish. Actin was used as reference protein.(D) Immunostaining of the zFbxo7 protein in eight-month-old zebrafish brain areas. The zFbxo7 immunoreactivity is shown in brown, while the cell nuclei are counterstained in blue using hematoxylin. The following areas are shown: olfactory bulb (OB), diencephalon (Di), optic tectum (TeO), medulla oblongata (MO), habenula (Ha), and cerebellum (C). Scale bars: 100 μm.

Expression Data

Gene:	fbxo7
Antibody:	Ab1-fbxo7
Fish:	WT
Anatomical Terms:	brain cerebellum diencephalon habenula heart liver medulla oblongata olfactory bulb optic tectum whole organism
Stage Range:	1-cell to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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