FIGURE

Fig. 5

ID

ZDB-FIG-121212-39

Publication

Gyda et al., 2012 - The tumor suppressor gene retinoblastoma-1 is required for retinotectal development and visual function in zebrafish

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Fig. 5

rb1^te226a retinas show delayed cell cycle exit during early retinogenesis.

Retinas removed from wild type (A, C, E) or rb1^te226a embryos (B, D, F) at 28 (A-B), 32 (C-D), or 36 hpf (E-F). Retinas labeled with anti-phosphohistone H3 antibody (green) to label M-phase nuclei and counterstained with DAPI (blue). Lateral view of maximum intensity projection of confocal z-stacks. Inner dashed circle outlines lens and outer dashed circle outlines retina. (G) Mean number of anti-phosphohistone-H3 labeled cells per retina. Error bars denote SEM. *p<0.01; one-way ANOVA with brackets indicating compared groups. N retinas shown at base of bar graphs. Anterior to the left, dorsal to the top of each panel. Scale bar = 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rb1^{te226a/te226a}
Observed In:	exit from mitosis
Stage Range:	Prim-5 to Prim-25

Phenotype Detail

Acknowledgments

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