FIGURE

Fig. 5

ID

ZDB-FIG-121001-10

Publication

Haas et al., 2011 - Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development

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Fig. 5

Zf12-LO is required for normal eye development. Sections of zf embryos were prepared and stained with Hematoxylin/Eosin. Morphological comparison of zf12-LO morphants (treated with MO-2) and controls (treated with MO-2 mis) was carried out with light microscopy at two dpf. Injection of MO-2 results in developmental eye abnormalities including loss of retinal layered structures and lens crystalline. RPE; retinal pigmented epithelium, RCL; rods and cones layer, OPL; outer plexiform layer, BCL; bipolar cell layer, ACL; amacrine cell layer, IPL; inner plexiform layer, GCL; ganglion cell layer. Similar results were obtained with zf12-LO morphants treated with MO-1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO2-alox12
Knockdown Reagent:	MO2-alox12
Observed In:	camera-type eye development eye lens lens development in camera-type eye retina layer formation
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA