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Fig. 2

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ZDB-FIG-120824-2

Publication

Kindt et al., 2012 - Kinocilia mediate mechanosensitivity in developing zebrafish hair cells

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Fig. 2

ovl/ift88 Mutant Hair Cells Lack Kinocilia yet Develop Normally(A and B) SEM image of an ift88^tz288b immature (A) and mature (B) hair bundle.(C and D) Tubulin and actin stain of bundles at 5 dpf in wild-type (WT) (C) and ift88^tz288b (D).(E) The average number of hair cells per neuromast at 2 dpf in wild-type and ift88^tz288b neuromasts (n > 13 neuromasts). ns, not significant.(F) Proportion of FM 1-43-labeled hair cells in ift88^tz288b and wild-type neuromasts at 2 dpf (n > 13 neuromasts).(G) The average FM 1-43 intensity per neuromast at 2 dpf (n > 13 neuromasts). a.u., arbitrary units.An unpaired Student’s t test was used to compare number of hair cells per neuromast in (E) and (G). A chi-square Fisher’s exact test was used to compare proportion of FM 1-43-labeled hair cells in (F). Scale bars, 500 nm (A and B) and 5 μm (C and D). Error bars are SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

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Acknowledgments

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Reprinted from Developmental Cell, 23(2), Kindt, K.S., Finch, G., and Nicolson, T., Kinocilia mediate mechanosensitivity in developing zebrafish hair cells, 329-341, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell