FIGURE

Fig. 6

ID

ZDB-FIG-120216-59

Publication

Langenbacher et al., 2012 - Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis

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Fig. 6

Atp1a1 expression by the YSL is regulated by mxtx1. (A–D) Microtome sections of atp1a1 expression in 95% epiboly (A,B) and 19S stage (C,D) wild type and mxtx1MO^YSL embryos. Nuclei are labeled red by neutral red staining. Expression of atp1a1 (purple staining, arrowheads) is present in the YSL of wild type embryos at 95% epiboly (A) and the 19S stage (C). The expression of atp1a1 in the YSL is strongly reduced in mxtx1MO^YSL embryos at the same stages (B,D). (G) Summary of Atp1a1 function. Atp1a1 expression in the YSL is regulated by mxtx1, and is required for the deposition of Fn/ECM around the developing heart. This ECM deposition is critical for normal heart tube elongation. Atp1a1 also has a cell autonomous role within cardiomyocytes to regulate the contractility of the heart.

Expression Data

Gene:	atp1a1a.1
Fish:	WT WT + MO1-mxtx1
Knockdown Reagent:	MO1-mxtx1
Anatomical Term:	yolk syncytial layer
Stage Range:	90%-epiboly to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 362(2), Langenbacher, A.D., Huang, J., Chen, Y., and Chen, J.N., Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis, 263-270, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.