FIGURE

Fig. 3

ID

ZDB-FIG-120214-14

Publication

Weinstein et al., 1996 - Hematopoietic mutations in the zebrafish

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Fig. 3

Blood cells are not properly generated during early stages of hematopoiesis in vmp and vlt mutants. Embryos were obtained from crosses between two vmp^m62 heterozygotes (A,B) or two vlt^m651 heterozygotes (C-F). (A,C,E) Phenotypically wild-type embryos. (B,D,F) Mutant siblings. (A,B) Wright-Giemsa stained longitudinal sections from the tails of 27 somite stage (approximately 22.5 hpf) mutant (B) and unaffected sibling (A) embryos. Erythroblasts are seen in both embryos (arrows), but there are many fewer are present in mutants. (C,D) Whole DAF stained 28 somite stage (23 hpf) phenotypically wild-type (C) and mutant (D) embryos. DAF staining is seen in the IMC of wild-type but not mutant embryos (arrows). (E,F) Wright-Giemsa stained longitudinal sections of 2.25 dpf phenotypically wild-type (E) and mutant (F) embryos. Normal blood cells are seen in wild-type embryos, but only abnormal, large cells are seen rarely in mutants (arrows). Scale bars 25 µm (A,B), 200 µm (C,D) and 50 µm (E,F).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gata1a^m651/m651 (AB) trim33^m62/m62
Observed In:	heme biosynthetic process nucleate erythrocyte
Stage Range:	26+ somites to Pec-fin

Phenotype Detail

Acknowledgments

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