FIGURE

Fig. 1

ID

ZDB-FIG-111115-11

Publication

O'Brien et al., 2011 - Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish

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Fig. 1

Characterization of podocyte development in zebrafish embryos. A) Schematic of pronephric development in zebrafish. B) Micrographs of in situ hybridizations show the expression patterns of early (wt1a, wt1b, mafba, hey1, lhx1a, pax2a) and mature (nephrin, podocin, podocalyxin, integrinα3) podocyte markers from 15 somites through 48 h of development. C) Analysis of podocyte development in relation to the surrounding tissues. Micrographs of in situ hybridizations compare podocyte (wt1b⁺, pax2a⁺ at 24 hpf), neck (pax2a⁺, wt1b^-), first proximal tubule segment (slc20a1a⁺) and interrenal (nr5a1a⁺) development at 24 hpf and 36 hpf. Cdh17⁺ cells represent all non-podocyte renal epithelia which includes both neck and tubule fates.

Expression Data

Genes:	cdh17 hey1 itga3b lhx1a mafba nphs1 nphs2 nr5a1a pax2a podxl slc20a1a wt1a wt1b
Fish:	TU
Anatomical Terms:	intermediate mesoderm interrenal primordium pronephric duct pronephric podocyte pronephric proximal straight tubule pronephric tubule somite
Stage Range:	14-19 somites to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 358(2), O'Brien, L.L., Grimaldi, M., Kostun, Z., Wingert, R.A., Selleck, R., and Davidson, A.J., Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish, 318-30, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.