FIGURE

Fig. 5

ID

ZDB-FIG-110909-25

Publication

Lewis et al., 2011 - Celsr3 Is Required for Normal Development of GABA Circuits in the Inner Retina

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Fig. 5

Cell localization and IPL organization are unchanged in the celsr3 mutant.

A) α-parvalbumin labels all displaced amacrine cells and a subpopulation of amacrines in the INL. B) counts of parvalbumin cells, displaced and normal amacrines were counted separately C) α-calretinin labels a subpopulation of amacrines in the INL and all ganglion cells. D) Counts of calretinin positive amacrine cells. E) α-CHAT stains a subpopulation of amacrine cells that laminate in 2 major and 2 minor sublaminae within the IPL. All sublaminae are present in the mutant. F) counts of CHAT positive amacrine cells in the INL G) Tg(ptf1a:Gal4VP16, UAS:mYFP) animals express mYFP in all amacrine and horizontal cells. H) Close ups of the IPL in Tg(ptf1a:Gal4VP16, UAS:mYFP) animals I) Images of Tg(GFAP:GFP) animals, which express GFP in all Müller cells. J) Counts of Müller cells per 50 μM. K) Tg(nyx:mYFP) animals express mYFP in the ON-bipolar cells. Scale bars are 20 μm.

Expression Data

Genes:	GFP YFP
Fish:	mi2003Tg celsr3^w65/w65; mi2003Tg jh16Tg; q16bTg mpv17^a9/a9; q16aTg; q16bTg celsr3^w65/w65; jh16Tg; q16bTg celsr3^w65/w65; mpv17^a9/a9; q16aTg; q16bTg
Anatomical Terms:	amacrine cell horizontal cell Muller cell ON-bipolar cell
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	celsr3^w65/w65 (AB) celsr3^w65/w65; mi2003Tg celsr3^w65/w65; jh16Tg; q16bTg celsr3^w65/w65; mpv17^a9/a9; q16aTg; q16bTg
Observed In:	amacrine cell horizontal cell Muller cell ON-bipolar cell retinal inner plexiform layer
Stage:	Day 6

Phenotype Detail

Acknowledgments

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