FIGURE

Fig. 5

ID

ZDB-FIG-110718-16

Publication

Becker et al., 2011 - Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish

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Fig. 5

Altered tnnt2 splicing induces significant changes in the expression of sarcomeric genes, neurohormonal genes and markers of hypertrophy. (A) Expression profiling identifies upregulation of myh6 (black bar) and confirms efficacy of TNNT2sp MO [white bar labeled ′tnnt2 (Exon 13)′. (B) Genes involved in cardiomyocyte Ca²⁺ handling that are differentially regulated in TNNT2sp morphants. (C) Pathway analysis identifies significant downregulation of expression of genes encoding specific hormones - ghrh, pth1a, pomca and uts2a. (D) qPCR confirmation of select up- and downregulated genes. All data expressed as mean + s.e.m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-tnnt2a
Knockdown Reagent:	MO3-tnnt2a
Observed In:	hormone activity
Stage:	Day 4

Phenotype Detail

Acknowledgments

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