FIGURE

Fig. 2

ID

ZDB-FIG-110624-2

Publication

Row et al., 2011 - Completion of the epithelial to mesenchymal transition in zebrafish mesoderm requires Spadetail

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Fig. 2

Mesoderm in spt morphants displays abnormal morphology. (A) Cells in the hypoblast of spt morphant embryos blebbed extensively and failed to adopt the proper mesenchymal morphology. (B) Cell protrusions were quantified in wild-type embryos during and after involution, in the hypoblast of spt morphants and in spt morphants expressing spt under the control of a heat shock-sensitive promoter. Mesodermal cells in spt morphants blebbed far more than in wild-type hypoblast, whereas restoring Spadetail significantly reduced this blebbing. Error bars indicate one standard deviation. At least 22 cells were quantified per condition. p < 0.05 for data marked with an asterisk.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-tbx16 + MO2-tbx16
Knockdown Reagents:	MO1-tbx16 MO2-tbx16
Observed In:	hypoblast bleb mesoderm mesodermal to mesenchymal transition involved in gastrulation
Stage Range:	Germ-ring to Shield

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 354(1), Row, R.H., Maître, J.L., Martin, B.L., Stockinger, P., Heisenberg, C.P., and Kimelman, D., Completion of the epithelial to mesenchymal transition in zebrafish mesoderm requires Spadetail, 102-110, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.