FIGURE

Fig. 3

ID

ZDB-FIG-110622-100

Publication

Nevin et al., 2011 - Topoisomerase II{beta} is required for lamina-specific targeting of retinal ganglion cell axons and dendrites

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Fig. 3

noto mutant tectal neurons have unrefined neuropil projections at 5 dpf. Sections of wild-type (A,C,E) and mutant (B,D,F) zebrafish tectum showing tectal cell populations and their neuropil neurites. Disorganized neuropil in the mutant is marked with asterisks. (A,B) Wild-type Parvalbumin (Parv)+ tectal neurons project neurites to four laminae in the neuropil; this laminar organization is incomplete in the mutant. (C,D) Wild-type Protein kinase C (PKC)+ tectal neurons project neurites to three laminae in the neuropil; this laminar organization is lost in the mutant. (E,F) Merged images showing relative location of laminae. Scale bar: 50 μm.

Expression Data

Antibodies:	Ab1-prkcb1 Ab1-pvalb
Fish:	WT top2b^s380/s380 (TL)
Anatomical Terms:	optic tectum axon optic tectum CNS neuron (sensu Vertebrata)
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	top2b^s380/s380 (TL)
Observed In:	optic tectum neuron projection retinal ganglion cell axon guidance
Stage:	Day 5

Phenotype Detail

Acknowledgments

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