FIGURE

Fig. 5

ID

ZDB-FIG-110527-27

Publication

Moussavi Nik et al., 2011 - The response of HMGA1 to changes in oxygen availability is evolutionarily conserved

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Fig. 5

A) Histogram showing the developmental stage attained by embryos at 24 h after fertilization when incubated in various concentrations of NaN3 from 6 hpf. Developmental stage is given as equivalent to the developmental age in hpf of embryos developing under normoxia at 28.5 °C. B) Nucleotide sequence alignment of the 3′ end of exon 5 in human PSEN2 and its orthologues. Red boxes enclose sequences aligned with the HMGA1a-binding sites in human PSEN2. C) RT-PCR on cDNA from zebrafish embryos amplifying a region spanning psen2 exons cognate to human PSEN2 exons 3 to 7 under hypoxic conditions and predicted PS2V-like splice product size. N.C. is a negative control (no DNA template in the PCR). No PCR product is observed at the 568 bp position predicted if the zebrafish exon cognate with human PSEN2 exon 5 was to be excluded.

Expression Data

Gene:	hmga1a
Fish:	WT
Condition:	hypoxia
Anatomical Terms:	brain whole organism
Stage Range:	Long-pec to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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