Fig. 1
- ID
- ZDB-FIG-110318-14
- Publication
- Miyasaka et al., 2011 - Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143
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Expression patterns of miR-143. (A) miR-143 is expressed in the brain (blue arrowhead), heart (red arrowhead) and somites of the posterior body part (blue bracket) at 36 hpf. (B) In a magnified view, expression is relatively restricted in the ventricular domain (V, red arrowhead). Atrial expression is not evident at this stage (A, blue arrowhead). The outline of the atrium is demarcated by a dotted line. (C and D) Ventricular expression (indicated by the letter V) is detected in both the myocardium (MYO) and the endocardium (ENDO). Expression is not observed in the atrial compartment (indicated by the letter A). The position of the A–V junction is indicated by blue arrowheads in C. (E) At 80 hpf, robust expression is evident in the OFT, while the ventricular expression (indicated by V) is less intense, and the endocardial expression is weak. miR-143 is not expressed in atrial regions (indicated by A). (F) At 5 dpf, the OFT expression becomes intense (red arrowhead), while the surrounding expression is detected in the head chondrocytes (blue arrowheads) and the branchial arches (blue bracket). (G) A schematic representation of miR-143 expression. miR-143 is expressed in a gradient manner, with the highest signals in the OFT and less intense ones in the ventricular myocardium. Neither endocardial nor myocardial expression is detected in the atrial compartment. |
Reprinted from Mechanisms of Development, 128(1-2), Miyasaka, K.Y., Kida, Y.S., Banjo, T., Ueki, Y., Nagayama, K., Matsumoto, T., Sato, M., and Ogura, T., Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143, 18-28, Copyright (2011) with permission from Elsevier. Full text @ Mech. Dev.