FIGURE

Fig. S2

ID

ZDB-FIG-101102-8

Publication

Bagnat et al., 2010 - Cse1l Is a Negative Regulator of CFTR-Dependent Fluid Secretion

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Fig. S2

Contribution of CFTR-Dependent Fluid Secretion to Cell Height and Microvilli (mv) Length Reduction in bao^s866 Mutant Enterocytes (Related to Figure 2)

(Ai) TEM micrographs of WT and bao^s866 mutant larvae treated with DMSO (control) or CFTR inhibitor T08 (5 μM). CFTR inhibition significantly increased cell height (measured from the basal membrane to the base of mv) and mv length in bao^s866 mutant enterocytes. GC: goblet cell. Scale bars represent 10 μm.

(Aii) Quantification of Ai. Error bars: SEM.

(Bi) TEM micrographs of WT larvae treated with DMSO (control) or CFTR activator Act9 (15 μM). CFTR activation in WT recapitulated the reduction in cell height and mv length observed in bao^s866 mutant enterocytes. Scale bars represent 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cse1l^s866/s866
Observed In:	enterocyte enterocyte microvillus
Stage:	Day 5

Phenotype Detail

Acknowledgments

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