FIGURE

Fig. 9

ID

ZDB-FIG-100806-64

Publication

Yang et al., 2010 - Regulatory interactions specifying Kolmer-Agduhr interneurons

Other Figures

All Figure Page

Back to All Figure Page

Fig. 9

gata2 and gata3 differentially regulate gad67 expression in KA′ and KA′ interneurons. (A-D) Zebrafish embryos injected with mismatch morpholino (A,C) or with morpholinos directed against gata2 mRNA (B,D). gata2 abolishes tal2 expression (B) as well as gad67 expression (D) in the lateral floor plate (arrow). Thus, correct differentiation of KA′ cells in the lateral floor plate requires gata2 function. (E-H) Embryos injected with mismatch morpholino (E,G) or morpholinos directed against gata3 mRNA (F,H). tal2 (E,F) and gad67 (G,H) expression in KA′ cells is abolished by gata3 knockdown (arrowhead), whereas expression in KA′ cells is unaffected (arrow). Embryos were 24 hpf. Anterior left, dorsal up. Scale bar: 25 μm.

Expression Data

Genes:	gad1b tal2
Fish:	WT WT + MO1-gata2a WT + MO1-gata3
Knockdown Reagents:	MO1-gata2a MO1-gata3
Anatomical Terms:	lateral floor plate Kolmer-Agduhr neuron spinal cord Kolmer-Agduhr neuron VeLD
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-gata2a WT + MO1-gata3
Knockdown Reagents:	MO1-gata2a MO1-gata3
Observed In:	lateral floor plate Kolmer-Agduhr neuron spinal cord Kolmer-Agduhr neuron ventral spinal cord interneuron differentiation
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development