FIGURE

Fig. 1

ID

ZDB-FIG-100520-21

Publication

Eames et al., 2010 - UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton

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Fig. 1

Craniofacial and skeletal phenotypes of zebrafish larvae. Ventral and lateral views of live (A, B, E, F, I, J, M, N) and Alcian blue-, Alizarin red-stained (C, D, G, H, K, L, O, P) animals. Compared to wild types (A, B), mutant animals (E,F mow^w60 allele; I, J hi3357 allele) had reduced lower jaws (arrows) at 5 dpf. Reduced lower jaw (arrow) in mow^w60/hi3357 double heterozygotes (M, N) showed failure of complementation. Alcian blue and Alizarin red staining for cartilage (blue) and bone (red) revealed the lack of cartilage and reduced bones in mutants (G, H, K, L) compared to wild type (C, D) at 7 dpf. Nomarski optics on dissected pharyngeal skeletons suggested that mutant cartilages (P) condensed in the same areas as wild types (O), but did not secrete Alcian blue-positive matrix. Abbreviations: cb1-5, ceratobranchials 1 to 5; ch, ceratohyal; cl, cleithrum; ep, ethmoid plate; hs, hyosymplectic; m, Meckel′s cartilage; op, opercle; pq, palatoquadrate; ps, parasphenoid.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	uxs1^w60/w60 uxs1^{hi3357Tg/hi3357Tg} uxs1^w60/+; uxs1^hi3357Tg/+
Observed In:	ceratobranchial 5 bone ceratobranchial cartilage ceratohyal bone ceratohyal cartilage chondrocranium cartilage hyomandibula Meckel's cartilage opercle palatoquadrate cartilage parasphenoid pectoral fin pharyngeal arch cartilage ventral mandibular arch whole organism
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 341(2), Eames, B.F., Singer, A., Smith, G.A., Wood, Z.A., Yan, Y.L., He, X., Polizzi, S.J., Catchen, J.M., Rodriguez-Mari, A., Linbo, T., Raible, D.W., and Postlethwait, J.H., UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton, 400-415, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.