FIGURE

Fig. 5

ID

ZDB-FIG-100513-18

Publication

Oppedal et al., 2010 - A Chemical Screen to Identify Novel Inhibitors of Fin Regeneration in Zebrafish

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Fig. 5

AGN192403 inhibits fin regeneration at multiple stages. (A, B) AGN192403 inhibits msx-b expression in the regenerating fin ray blastema. Whole-mount in situ hybridization demonstrates a dramatic reduction in msx-b transcript (arrows) in AGN192403-treated fish (A) compared with controls (B). (C) AGN192403 inhibits the outgrowth stage of fin regeneration. After fin amputation, zebrafish were treated with AGN192403 (or DMSO [open squares]) either from days 2–7 (open triangles) or days 7–12 (open circles) postamputation. Regeneration was inhibited regardless of whether AGN192403 was added during the early (days 2–7) or late (days 5–12) stages of outgrowth.

Expression Data

Gene:	msx1b
Fish:	AB
Condition:	amputation: dorsal fin lepidotrichium
Anatomical Term:	caudal fin lepidotrichium blastema
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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