FIGURE

Fig. 5

ID

ZDB-FIG-100309-79

Publication

Lorent et al., 2010 - Reiterative use of the notch signal during zebrafish intrahepatic biliary development

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Fig. 5

Notch signaling is required for canalicular development. Confocal projections (5 μm) through the liver of a 70-hpf larva (A) and two 92-hpf (C, D) larvae treated with DAPT from 48-70 hpf (A); DAPT from 48-92 hpf (C) and DAPT from 48-70 hpf (D). A 70-hpf (B) and 92-hpf wild type larva (E) are also shown. All larvae were immunostained with Mdr (red) and 2F11 (green) antibodies. DAPT treatment arrests canalicular development (red) and biliary development (green). Canalicular development reinitiates with DAPT withdrawal (D). Note that the depth of these confocal projections is too small to detect reinitiation of duct development upon DAPT withdrawal.

Expression Data

Antibodies:	Ab-2F11 Ab1-mdr
Fish:	TL
Condition:	chemical treatment: DAPT
Anatomical Terms:	bile canaliculus liver and biliary system
Stage Range:	Pec-fin to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL
Condition:	chemical treatment: DAPT
Observed In:	bile canaliculus intrahepatic bile duct development liver development
Stage Range:	Pec-fin to Protruding-mouth

Phenotype Detail

Acknowledgments

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