FIGURE

Fig. 4

ID

ZDB-FIG-100302-79

Publication

Bai et al., 2010 - Disruption of zebrafish cyclin G-associated kinase (GAK) function impairs the expression of Notch-dependent genes during neurogenesis and causes defects in neuronal development

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Fig. 4

Both zGAK and zAux can substitute for Drosophila auxilin. Fluorescent micrographs of Drosophila eye imaginal discs stained with αElav antibody, which labels the nuclei of the neuronal cells (blue). The expressions of zebrafish and Drosophila auxilin genes are shown in green. Homozygous dAux^F956* mutant tissues are indicated by the absence of the membrane-associated mRFP (red). Regions containing excessive Elav-positive cells are indicated by arrows. All the flies carry Act5C-GAL4, UAS-FLP on the second chromosome, and other relevant genotypes include: (A) FRT^5-5Z3515, dAux^F956*/FRT^5-5Z3515, GMR-src-mRFP, (B) UAS-dAux-GFP; FRT^5-5Z3515, dAux^F956*/FRT^5-5Z3515, GMR-src-mRFP, (C) UAS-GFP-zGAK; FRT^5-5Z3515, dAux^F956*/FRT^5-5Z3515, GMR-src-mRFP, (D) UAS-GFP-zAux; FRT^5-5Z3515, dAux^F956*/FRT^5-5Z3515, GMR-src-mRFP, (E) UAS-GFP-zGAK^ΔJ; FRT^5-5Z3515, dAux^F956*/FRT^5-5Z3515, GMR-src-mRFP, and (F) UAS-GFP-zAux^ΔJ; FRT^5-5Z3515, dAux^F956*/FRT^5-5Z3515, GMR-src-mRFP. Scale Bar, 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.